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2 edition of In vivo and in vitro studies on cyclosporine-induced nephrotoxicity found in the catalog.

In vivo and in vitro studies on cyclosporine-induced nephrotoxicity

Hilary Clarke

In vivo and in vitro studies on cyclosporine-induced nephrotoxicity

by Hilary Clarke

  • 382 Want to read
  • 3 Currently reading

Published by University College Dublin in Dublin .
Written in English

    Subjects:
  • Toxicity testing in vivo.,
  • Toxicity testing in vitro.

  • Edition Notes

    Statementby Hilary Clarke.
    ContributionsUniversity College Dublin. Department of Pharmacology.
    The Physical Object
    Pagination(6), v, 159p., several p.ages of plates ;
    Number of Pages159
    ID Numbers
    Open LibraryOL17488622M

    Effect of Garlic Oil on Cyclosporine Induced Renal Toxicity in Rats Study of in Vitro and in Vivo Drug Effects on Cell Mediated Cytotoxicity,” acute and chronic nephrotoxicity . In this study we proposed a combination product containing both gentamicin and α-tocopherol and tested it in vivo. The product was proposed after in vivo studies, as well as in a human study demonstrating nephrotoxicity protection benefits when vitamin E was administered days prior to gentamicin administration [17,22,23,24].Cited by: 1.

      The dose and length of CsA administration was chosen since nowadays, it is normally accepted that 15 mg/kg/day CsA induces acute and chronic nephrotoxicity on the basis of the time treatment. The dose of DOPET was chosen on the basis of the previous in vitro study [ 21] Superoxide assay in the dissected aorta and renal arteryCited by: some and autophagy regulation using both in vitro and in vivo models. Results TMBIM6 increases autophagy, cell viability, and suppresses ER stress in CsA-treated human kidney cells CsA-induced renal injury has been linked to alterations of autophagic clearance In this study, we examined the effect ofCited by:

    Renal proton nuclear magnetic resonance in gentamicin, cyclosporin A and cisplatinum, acute renal failure in rats.- 31Phosphorus NMR studies of mercuric chloride nephrotoxicity in the in vitro perfused rat kidney When cell cultures are used for in vitro nephrotoxicity studies, the cells are usually grown on a solid surface, which allows only apical treatment with xenobiotics. However, in vivo, xenobiotics can gain access to the proximal tubule cell from the apical as well as from the basolateral by: 3.


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Repealing Act of Congress. Memorial of the legislative assembly of the Territory of Arizona, asking that the Act of Congress, approved May 5, A.D. 1866, setting off to the State of Nevada all that part of the territory of Arizona west of the 37th degree of longitude west from Washington, and the west of the Colorado River, be repealed.

Repealing Act of Congress. Memorial of the legislative assembly of the Territory of Arizona, asking that the Act of Congress, approved May 5, A.D. 1866, setting off to the State of Nevada all that part of the territory of Arizona west of the 37th degree of longitude west from Washington, and the west of the Colorado River, be repealed.

In vivo and in vitro studies on cyclosporine-induced nephrotoxicity by Hilary Clarke Download PDF EPUB FB2

Cyclosporine is a unique immunosuppressive agent that inhibits activation of both B and T lymphocytes as well as certain macrophage functions; however, the predominant effect of Cited by: There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed.

Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or. In vitro, cyclosporine A reduced the rate of proliferation of rabbit aortic smooth muscle and endothelial cells in a dose-dependent fashion, and induced smooth muscle cell vacuolation.

These data suggest that cyclosporine A may contribute to Cited by: Experimental in vivo and in vitro studies have found that cyclosporine-induced functional derangements were accompanied by oxidant stress, 33, 34, 35 Results regarding CSA effect on glutathione renal content showed decreased glutathione levels or increased tissue concentrations of oxidized and reduced glutathione If we consider the pivotal role of.

There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed. Thus n. The aim of this study was to investigate the protective effects of Sch B on cyclosporine A (CsA)-induced nephrotoxicity in mice and HK-2 cells (a human proximal tubular epithelial cell line).

After gavage with Sch B (20 mg/kg) or olive oil (vehicle), mice received CsA (30 mg/kg) by subcutaneous injection once daily for four by: These in vitro systems have allowed us to examine the role of transport and biotransformation, and to compare potency and mechanism of nephrotoxic chemicals.

Although in vitro systems cannot totally duplicate or replace in vivo toxicity studies, they are a Cited by: Cyclosporine (CsA) is the current primary immunosuppressant for the prevention of allograft rejection in solid organ transplantation. However, owing to its molecular mechanism of action the drug is associated with various adverse side effects (eg, nephrotoxicity).

Chronic Nephrotoxicity. The most notably referenced study linking cyclosporine with chronic nephrotoxicity was that done in by Myers et al.

in which recipients of cardiac transplants surviving greater than 12 months and treated with CsA were compared to a similar group transplanted prior to who received azathioprine and by: Scherrer U, Vissing SF, Morgan BJ, et al.

Cyclosporine-induced sympathetic activation and hypertension after heart transplantation. N Engl J Med ; Wissmann C, Frey FJ, Ferrari P, Uehlinger DE.

Acute cyclosporine-induced nephrotoxicity in renal transplant recipients: the role of the transplanted kidney. J Am Soc Nephrol ; Although cisplatin can dramatically improve the survival rate in cancer patients, its use is limited by its nephrotoxicity.

Previous investigations showed that Panax ginseng contains components that exhibit protective activity against cisplatin-induced nephropathy. The aim of the present study is to investigate the effect of microwave-assisted processing on the protective effect of ginseng Cited by: To investigate the therapeutic effects of BMSCs pretreated with EPO in CsA‐induced nephrotoxicity, we established CsA‐induced in vitro and in vivo toxicity models.

In our in vitro study, preconditioning of BMSCs with IU/mL EPO for 48 h induced a marked increase in their proliferation rate, cytoskeletal rearrangement, migration in the Cited by: 2. susceptible to CsA nephrotoxicity. Moreover, great at- tention should be paid to drug interactions: Table 1.

lists the drugs that may increase the risk of CsA-associated nephrotoxicity. Finally, determination of a patient’s or donor’s genotype of drug-metabolizing genes or of mol- ecules involved in CsA nephrotoxicity, like TGF-β, couldFile Size: KB.

Oxidative stress is the main mechanism resulting in cyclosporine-induced nephrotoxicity. Because of its ability to stimulate endogenous melatonin production, isoproterenol is. In a rat model of whole-body exposure to traffic-related PM, PM in urban ambient air affected kidney function and induced autophagy, ER stress and apoptosis in kidney tissues.

This study provides experimental evidence both in vitro and in vivo that exposure to particulate air pollution can cause kidney damage. Based on these results, we conclude that efforts to improve air quality in the future might ease the burden of kidney by: 5.

Aim: The nephrotoxicity and immunosuppressive ability of cyclosporine (CyA) incorporated into polycaprolactone nanoparticles (CyA-NP) was assessed in vitro and in vivo and compared to the effects caused by free drug (Sandimmun ®).Cited by: The purpose of this study was to determine the nephrotoxic potential of propanil using an in vitro kidney model, determine whether in vitro propanil nephrotoxicity is due to metabolites arising from propanil hydrolysis, and examine mechanistic aspects of propanil nephrotoxicity in vitro.

Propanil, 3,4-DCA, propionic acid (– mM), or vehicle was incubated for 15– Cited by: Correlative studies in vivo revealed decreased bcl-2 and increased bax gene expression in the renal cortex of diabetic db/db mice, and this was associated with increased apoptotic index in.

The aim of this research was to investigate the antioxidant and anti-apoptotic activities of Potentilla anserina polysaccharide (PAP) on kidney damage induced by cadmium (Cd) in vitro and in has been suggested to have anti-oxidation, anti-apoptosis, immunoregulation, antimicrobial, antitussive, and expectorant abilities.

Results and conclusion. Animal studies show beneficial effects of various antioxidants, such as erdosteine, vitamin E, vitamin C, N-acetylcysteine, caffeic acid phenethyl ester, and erythropoietin, in the prevention of vancomycin-induced r, before these agents can be used in clinical practice, their potential benefits must be confirmed in future Cited by:.

In general, in vitro studies are consistent with a role for decreased LDL receptor expression or activity in liver cells after exposure to CsA [48,56].

In vivo studies however, show mixed effects, with no effect or an increase in hepatic LDLr protein or mRNA levels [49,50].Cited by: 4.The aim of the present study was the in vitro and in vivo evaluation of a novel aqueous formulation based on polymeric micelles for the topical .To investigate the therapeutic effects of BMSCs pretreated with EPO in CsA‐induced nephrotoxicity, we established CsA‐induced in vitro and in vivo toxicity models.

In our in vitro study.